Single factor, the impact of topiramate non-Nepalese ketone liposome encapsulation efficiency, particle size and particle size distribution and other factors on the basis of the basic prescription, select the four main factors orthogonal design, optimized prescription and preparation process.

In the basic recipe, on the basis of the affected joint, methadone liposomes encapsulating rate, particle size, such as size and particle size distribution with a single factor, factor 4 of the main factors in orthogonal design research, optimization of the prescription and the preparation process.

In the basic prescription foundation, to affects, particle size size and grain-size distribution factors and so on the pyrrole non-Nepal alkone lipin body envelope rate carries on the single factor inspection, chooses 4 primary factors to conduct the orthogonal design research, obtains the optimized

Basic prescription on the basis of, on the effect of non-effect of liposome entrapment, such factors as particle size and particle size distribution for single factors, select the orthogonal design study 4 major factors, optimized recipe and preparation process.

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