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關注:1
2013-05-23 12:21
求翻譯:The reason for this discrepancy is unclear, but, considering that Mdm2 mRNA levels are elevated in the absence of Pict1 ,a previously uncharacterized post-transcriptional mechanism may suppress Mdm2 protein without Pict1. The low p53 ubiquitination in Dox+ cells is not simply due to low p53-Mdm2 binding ,and is probabl是什么意思?![]() ![]() The reason for this discrepancy is unclear, but, considering that Mdm2 mRNA levels are elevated in the absence of Pict1 ,a previously uncharacterized post-transcriptional mechanism may suppress Mdm2 protein without Pict1. The low p53 ubiquitination in Dox+ cells is not simply due to low p53-Mdm2 binding ,and is probabl
問題補充: |
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2013-05-23 12:21:38
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2013-05-23 12:23:18
正在翻譯,請等待...
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2013-05-23 12:24:58
這差誤的原因是不明的,但,考慮Mdm2 mRNA水平在沒有Pict1時是高的,一個早先uncharacterized崗位transcriptional機制也許壓制Mdm2蛋白質,不用Pict1。 低p53 ubiquitination在Dox+細胞不簡單地歸結于低p53-Mdm2捆綁和由Mdm2的E3連接酶作用的鈍化作用Pict1損失導致的大概造成。
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2013-05-23 12:26:38
這種差異的原因尚不清楚,但是,考慮 Mdm2 mRNA 水平提高 Pict1 簡明沒有以前無特征的轉錄機制不得壓制 Mdm2 蛋白無 Pict1。單元格中都喜哈嘎 + 低的 p53 泛并不只是因為要低的 p53 Mdm2 綁定辛苦,可能引起的滅活 E3 連接酶功能的 Mdm2 Pict1 的損失所致。
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2013-05-23 12:28:18
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